A Case of Punctate Psoriasis Following Treatment with Cetuximab in a Patient with Metastatic Gastric Adenocarcinoma.

Background: In contemporary times, malignancies characterized by metastatic growth have been subjected to innovative therapeutic approaches involving immunological agents known as Programmed Death Receptor 1 (PD-1) inhibitors. Notwithstanding their remarkable immunotherapeutic effectiveness, these treatments can give rise to undesirable immune-related effects. Sintilimab, a PD-1 inhibitor sanctioned for marketing by the Chinese National Medical Products Administration in 2018, has been associated with 51 reported cases of adverse reactions on the market, excluding psoriasis, up to the present moment. Case Description: Herein, we report the clinical characteristics of a patient with metastatic gastric adenocarcinoma who developed guttate psoriasis after receiving Sintilimab. The patient was an elderly male presenting with papules varying in size from that of rice grains to soybeans, accompanied by scattered erythematous lesions across his body. Notably, an atypical Auspitz's sign was observed, wherein certain lesions were covered with a minimal amount of scale, coupled with reported persistent itching. The progression of the disease manifested within a span of one week. Conclusion: PD1 inhibitors have been associated with the recurrence, exacerbation, or new onset of psoriasis. Consequently, a personal or family history of psoriasis is an essential risk factor that needs to be considered before PD1 inhibitor medication, which helps with the early diagnosis of psoriasis. Early diagnosis of new-onset guttate psoriasis poses challenges. An early consultation with a dermatologist is recommended, and a conclusive diagnosis can be obtained through a histopathologic examination.

A Study on the Clinical Significance of Blood Exosomal PD-L1 in Non-Small Cell Lung Cancer Patients and its Correlation with PD-L1 in Tumor Tissues.

Exosomal programmed cell-death ligand 1 (ePD-L1) can influence immune inhibition and dysfunction. We were dedicated to unearthing the relation between ePD-L1 in blood and pathological characteristics as well as PD-L1 in tumor tissues. We recruited 65 non-small cell lung cancer (NSCLC) patients for exosome extraction and detected the blood ePD-L1 expression in these patients by enzyme-linked immunosorbent assay (ELISA) method. Besides, the correlation between blood ePD-L1 and patients' pathological characteristics was also analyzed. The expression of PD-L1 in tumor tissues was tested by immunohistochemistry (IHC) and its correlation with blood ePD-L1 expression level was analyzed by Spearman correlation coefficient. No significant correlation was observed in PD-L1 expression levels between blood-derived exosome and tumor tissue. Altogether, high blood ePD-L1 expression was relevant to NSCLC progression, while no such relevance to PD-L1 expression in tumor tissue.

Partially selenized FeCo layered double hydroxide as bifunctional electrocatalyst for efficient and stable alkaline (sea)water splitting.

Seawater electrolysis to produce hydrogen is a clean and sustainable strategy for the development of clean and sustainable energy storage systems. However, the erosion and destruction of electrocatalysts of the devices by Cl- in seawater during splitting process make it very difficult to realize. In this work, a partially selenized FeCo layered double hydroxide (Se-FeCo-LDH) catalyst is successfully synthesized, which shows good electrocatalytic performance in seawater during water splitting due to both its excellent conductivity and large surface area. Moreover, an anion aggregation layer around the electrode during the catalytic process can be formed to avoid electrode erosion and destruction by Cl- as well as the competitive reaction of chloride oxidation with the oxygen evolution reaction (OER), which not only improves the catalytic efficiency but also the durability of the catalyst. As a result, the overpotential is only 229 mV at a current density of 100 mA cm-2 for OER in 1 M KOH. Only 1.446 V and 1.491 V voltages are required to reach a current density of 10 mA cm-2 in overall alkaline water and seawater splitting, respectively. Besides, this Se-FeCo-LDH catalyst also achieves long-term stability up to 245 h in overall alkaline seawater splitting. The development of Se-FeCo-LDH catalyst should have an enlightening effect in the field of hydrogen production by (sea)water electrolysis.

Rh-Catalyzed Coupling Reactions of Fluoroalkyl N-Sulfonylhydrazones with Azides Leading to α-Trifluoroethylated Imines.

Herein we describe the pioneering Rh-catalyzed coupling reactions of a fluoroalkyl carbene with azides to access α-trifluoroethylated imines, where fluoroalkyl N-sulfonylhydrazones are used as fluoroalkyl diazo surrogates. Remarkably, using TMSN3 as the N source, two C-N bond formation products were obtained. Furthermore, the α-trifluoroethylated imine products could be easily reduced to the corresponding N-trifluoroethylated anilines. Experimental results and theoretical calculations justify a stepwise reaction pathway involving the formation of rhodium carbene, the addition of HN3, and C═N bond formation.

Prussian blue analogues derived electrocatalyst with multicatalytic centers for boosting oxygen reduction reaction in the wide pH range.

Due to the complex of oxygen reduction reaction (ORR), designing catalysts with multicatalytic centers is considered as a promising way for boosting the ORR. Herein, a multicatalytic centers electrocatalyst Fe3C/Mn3O4 encased by N-doped graphitic layers (FeMn PDA-900) is synthesized using iron manganese Prussian blue analogues and dopamine as the precursor. It exhibits a half-wave potential (E1/2) of 0.86 V for ORR and yields of H2O2 lower than 5% in 0.1 M KOH. Moreover, the prepared catalyst has also shown high catalytic ORR performance in both acidic and neutral electrolyte solutions, which exhibits the potential application in both the proton exchange membrane fuel cell and the microbial electrolysis cell. It is found that the good performance can be well explained by proton-coupled electron transfer mechanism due to the multicatalytic centers from Fe-Nx, Fe3C and Mn3O4 for providing enough active sites at the same time and the N-doped graphitic layers as a bridge for facilitating the electron transfer between the interfaces of Fe3C/Mn3O4 nanoparticles, which paves the way for protons and electrons transfer simultaneously and rapidly, and thus lowing the energy barrier and facilitating the ORR process. Therefore, FeMn PDA-900 is a promising candidate to replace precious metal-based ORR electrocatalysts at the whole pH range.

High performance benzoimidazolyl-based aminophenolate zinc complexes for isoselective polymerization of rac-lactide.

Zinc complexes supported by achiral benzoimidazolyl-based aminophenolate ligands exhibit high catalytic activities and excellent isoselectivities toward the ring-opening polymerization of rac-lactide under mild conditions.

Facile synthesis of Sb2S3/MoS2 heterostructure as anode material for sodium-ion batteries.

A novel Sb2S3/MoS2 heterostructure in which Sb2S3 nanorods are coated with MoS2 nanosheets to form a core-shell structure has been fabricated via a facile two-step hydrothermal process. The Sb2S3/MoS2 heterostructure utilized as the anode of sodium-ion batteries (SIBs) shows higher capacity, superior rate capability and better cycling performance compared with individual Sb2S3 nanorods and MoS2 nanosheets. Specifically, the Sb2S3/MoS2 electrode shows an initial reversible capacity of 701 mAh g-1 at a current density of 100 mA g-1, which then remains at 80.1% of the initial performance after 100 cycles at the same current density. This outstanding electrochemical performance indicates that the Sb2S3/MoS2 heterostructure is a very promising anode material for high-performance SIBs.

Effect of amitriptyline on gastrointestinal function and brain-gut peptides: a double-blind trial.

AIM: To study the effects of low-dose amitriptyline (AMT) on gastrointestinal function and brain-gut peptides in healthy Chinese volunteers. METHODS: This was a double-blind, randomised, placebo-controlled, two-period cross-over trial. Twenty-eight healthy volunteers were randomised and administered 1-wk treatments of AMT (12.5 mg tid) or placebo. Before and during the final two days of treatment, gastric emptying, proximal gastric accommodation and visceral sensitivity were measured by drinking-ultrasonography test; the orocecal transit time (OCTT) was measured by lactulose hydrogen breath test, and fasting blood was collected. Plasma levels of ghrelin, motilin and neuropeptide Y (NPY) were measured by enzyme-linked immunosorbent assay kits. RESULTS: AMT slowed the OCTT (109.2 ± 29.68 min vs 96.61 ± 23.9 min, P = 0.004) but did not affect liquid gastric emptying and had no effect on proximal gastric accommodation. AMT resulted in decreases in the visual analogue scale (VAS) for difficulty in drinking 600 and 800 mL of water (3.57 ± 0.94 vs 2.98 ± 0.85, 5.57 ± 0.82 vs 4.57 ± 0.98, P < 0.01 for both), although it had no significant effect on the VAS for difficulty in drinking 200 mL and 400 mL of water. AMT significantly increased the plasma ghrelin level (442.87 ± 176.79 pg/mL vs 526.87 ± 158.44 pg/mL, P = 0.04) and the neuropeptide-Y level (890.15 ± 131.46 pg/mL vs 965.64 ± 165.63 pg/mL, P = 0.03), whereas it had no effect on the MTL level. CONCLUSION: Low-dose AMT could slow OCTT, make the stomach less sensitive and increase the plasma levels of ghrelin and NPY. Thus, we recommend the use of low-dose AMT for functional gastrointestinal disorders.

'Seeding' with protease to optimize protein crystallization conditions in in situ proteolysis.

In situ proteolysis is one of the most effective rescue strategies for protein crystallization, and optimization of the ratio between the protein and the protease is one of the key steps in the process. Seeding is a very powerful tool to optimize crystallization conditions and can be performed by most crystallization robots. Addition of protease instead of seed stock using a robot can be used to optimize the concentration of protease in in situ proteolysis experiments and has been successfully tested using two proteins.